diff --git a/pkgs/development/compilers/vlang/default.nix b/pkgs/development/compilers/vlang/default.nix
index f72ec0890543..d49d651a6ca5 100644
--- a/pkgs/development/compilers/vlang/default.nix
+++ b/pkgs/development/compilers/vlang/default.nix
@@ -1,42 +1,47 @@
-{ stdenv, fetchFromGitHub, glfw, freetype, openssl }:
+{ stdenv, fetchFromGitHub, glfw, freetype, openssl, upx ? null }:
+
+assert stdenv.hostPlatform.isUnix -> upx != null;
 
 stdenv.mkDerivation rec {
   pname = "vlang";
-  version = "0.1.18";
+  version = "0.1.21";
 
   src = fetchFromGitHub {
     owner = "vlang";
     repo = "v";
     rev = version;
-    sha256 = "0js92v2r1h4vaaha3z1spgi7qynlmr9vls41gxp284w4yhnjzv15";
+    sha256 = "0npd7a7nhd6r9mr99naib9scqk30209hz18nxif27284ckjbl4fk";
   };
 
   # V compiler source translated to C for bootstrap.
+  # Use matching v.c release commit for now, 0.1.21 release is not available.
   vc = fetchFromGitHub {
     owner = "vlang";
     repo = "vc";
-    rev = version;
-    sha256 = "0qx1drs1hr94w7vaaq5w8mkq7j1d3biffnmxkyz63yv8573k03bj";
+    rev = "950a90b6acaebad1c6ddec5486fc54307e38a9cd";
+    sha256 = "1dh5l2m207rip1xj677hvbp067inw28n70ddz5wxzfpmaim63c0l";
   };
 
   enableParallelBuilding = true;
-  buildInputs = [ glfw freetype openssl ];
+  buildInputs = [ glfw freetype openssl ]
+    ++ stdenv.lib.optional stdenv.hostPlatform.isUnix upx;
 
   buildPhase = ''
     runHook preBuild
     cc -std=gnu11 $CFLAGS -w -o v $vc/v.c -lm $LDFLAGS
-    ./v -prod -o v compiler
-    make thirdparty
+    ./v -prod -cflags `$CFLAGS` -o v compiler
+    # Exclude thirdparty/vschannel as it is windows-specific.
+    find thirdparty -path thirdparty/vschannel -prune -o -type f -name "*.c" -execdir cc -std=gnu11 $CFLAGS -w -c {} ';'
     runHook postBuild
   '';
 
   installPhase = ''
     runHook preInstall
-    mkdir -p $out/{bin,lib/vlang,share/vlang}
-    cp -r examples $out/share/vlang
-    cp -r {vlib,thirdparty} $out/lib/vlang
-    cp v $out/lib/vlang
-    ln -s $out/lib/vlang/v $out/bin/v
+    mkdir -p $out/{bin,lib,share}
+    cp -r examples $out/share
+    cp -r {vlib,thirdparty} $out/lib
+    cp v $out/lib
+    ln -s $out/lib/v $out/bin/v
     runHook postInstall
   '';