diff --git a/pkgs/applications/video/mpv/default.nix b/pkgs/applications/video/mpv/default.nix
index bb0b92eee030..2a8a0a64274f 100644
--- a/pkgs/applications/video/mpv/default.nix
+++ b/pkgs/applications/video/mpv/default.nix
@@ -1,6 +1,6 @@
 { config, stdenv, fetchurl, fetchFromGitHub, makeWrapper
-, docutils, perl, pkgconfig, python3, which, ffmpeg_4
-, freefont_ttf, freetype, libass, libpthreadstubs, mujs
+, addOpenGLRunpath, docutils, perl, pkgconfig, python3, which
+, ffmpeg_4, freefont_ttf, freetype, libass, libpthreadstubs, mujs
 , nv-codec-headers, lua, libuchardet, libiconv ? null, darwin
 
 , waylandSupport ? stdenv.isLinux
@@ -135,8 +135,7 @@ in stdenv.mkDerivation rec {
   '';
 
   nativeBuildInputs = [
-    docutils makeWrapper perl
-    pkgconfig python3 which
+    addOpenGLRunpath docutils makeWrapper perl pkgconfig python3 which
   ];
 
   buildInputs = [
@@ -214,11 +213,17 @@ in stdenv.mkDerivation rec {
       ${wrapperFlags}
   '';
 
+  # Set RUNPATH so that libcuda in /run/opengl-driver(-32)/lib can be found.
+  # See the explanation in addOpenGLRunpath.
+  postFixup = optionalString stdenv.isLinux ''
+    addOpenGLRunpath $out/bin/.mpv-wrapped
+  '';
+
   meta = with stdenv.lib; {
     description = "A media player that supports many video formats (MPlayer and mplayer2 fork)";
     homepage = https://mpv.io;
     license = licenses.gpl2Plus;
-    maintainers = with maintainers; [ AndersonTorres fuuzetsu fpletz globin ];
+    maintainers = with maintainers; [ AndersonTorres fuuzetsu fpletz globin ivan ];
     platforms = platforms.darwin ++ platforms.linux;
 
     longDescription = ''
diff --git a/pkgs/development/libraries/ffmpeg/generic.nix b/pkgs/development/libraries/ffmpeg/generic.nix
index 4c0ca0210cc8..b3310e44ae06 100644
--- a/pkgs/development/libraries/ffmpeg/generic.nix
+++ b/pkgs/development/libraries/ffmpeg/generic.nix
@@ -1,4 +1,4 @@
-{ stdenv, fetchurl, pkgconfig, perl, texinfo, yasm
+{ stdenv, fetchurl, pkgconfig, addOpenGLRunpath, perl, texinfo, yasm
 , alsaLib, bzip2, fontconfig, freetype, gnutls, libiconv, lame, libass, libogg
 , libssh, libtheora, libva, libdrm, libvorbis, libvpx, lzma, libpulseaudio, soxr
 , x264, x265, xvidcore, zlib, libopus, speex, nv-codec-headers, dav1d
@@ -42,7 +42,7 @@
 
 let
   inherit (stdenv) isDarwin isFreeBSD isLinux isAarch32;
-  inherit (stdenv.lib) optional optionals enableFeature;
+  inherit (stdenv.lib) optional optionals optionalString enableFeature;
 
   cmpVer = builtins.compareVersions;
   reqMin = requiredVersion: (cmpVer requiredVersion branch != 1);
@@ -157,7 +157,7 @@ stdenv.mkDerivation rec {
       "--enable-cross-compile"
   ] ++ optional stdenv.cc.isClang "--cc=clang";
 
-  nativeBuildInputs = [ perl pkgconfig texinfo yasm ];
+  nativeBuildInputs = [ addOpenGLRunpath perl pkgconfig texinfo yasm ];
 
   buildInputs = [
     bzip2 fontconfig freetype gnutls libiconv lame libass libogg libssh libtheora
@@ -186,6 +186,10 @@ stdenv.mkDerivation rec {
       substituteInPlace $pc \
         --replace "includedir=$out" "includedir=''${!outputInclude}"
     done
+  '' + optionalString stdenv.isLinux ''
+    # Set RUNPATH so that libnvcuvid in /run/opengl-driver(-32)/lib can be found.
+    # See the explanation in addOpenGLRunpath.
+    addOpenGLRunpath $out/lib/libavcodec.so*
   '';
 
   installFlags = [ "install-man" ];