diff --git a/pkgs/desktops/gnome/apps/ghex/default.nix b/pkgs/desktops/gnome/apps/ghex/default.nix
index bd68b393c3cc..d78fb3fc2019 100644
--- a/pkgs/desktops/gnome/apps/ghex/default.nix
+++ b/pkgs/desktops/gnome/apps/ghex/default.nix
@@ -54,6 +54,9 @@ stdenv.mkDerivation rec {
 
   mesonFlags = [
     "-Dgtk_doc=true"
+  ] ++ lib.optionals stdenv.isDarwin [
+    # mremap does not exist on darwin
+    "-Dmmap-buffer-backend=false"
   ];
 
   postFixup = ''