diff --git a/pkgs/development/libraries/libaom/default.nix b/pkgs/development/libraries/libaom/default.nix
index 9706cda03f8b..0522cdf2d500 100644
--- a/pkgs/development/libraries/libaom/default.nix
+++ b/pkgs/development/libraries/libaom/default.nix
@@ -32,6 +32,9 @@ stdenv.mkDerivation rec {
   cmakeFlags = [
     "-DBUILD_SHARED_LIBS=ON"
     "-DENABLE_TESTS=OFF"
+  ] ++ lib.optionals stdenv.isDarwin [
+    # CPU detection isn't supported on Darwin and breaks the aarch64-darwin build:
+    "-DCONFIG_RUNTIME_CPU_DETECT=OFF"
   ];
 
   postFixup = ''