diff --git a/changelog.d/4757.misc b/changelog.d/4757.misc
new file mode 100644
index 000000000..42bb66f7a
--- /dev/null
+++ b/changelog.d/4757.misc
@@ -0,0 +1 @@
+When presence is disabled don't send over replication.
diff --git a/synapse/federation/federation_server.py b/synapse/federation/federation_server.py
index 569eb277a..81f3b4b1f 100644
--- a/synapse/federation/federation_server.py
+++ b/synapse/federation/federation_server.py
@@ -886,6 +886,9 @@ class ReplicationFederationHandlerRegistry(FederationHandlerRegistry):
     def on_edu(self, edu_type, origin, content):
         """Overrides FederationHandlerRegistry
         """
+        if not self.config.use_presence and edu_type == "m.presence":
+            return
+
         handler = self.edu_handlers.get(edu_type)
         if handler:
             return super(ReplicationFederationHandlerRegistry, self).on_edu(
diff --git a/synapse/replication/slave/storage/presence.py b/synapse/replication/slave/storage/presence.py
index 92447b00d..9e530defe 100644
--- a/synapse/replication/slave/storage/presence.py
+++ b/synapse/replication/slave/storage/presence.py
@@ -54,8 +54,11 @@ class SlavedPresenceStore(BaseSlavedStore):
 
     def stream_positions(self):
         result = super(SlavedPresenceStore, self).stream_positions()
-        position = self._presence_id_gen.get_current_token()
-        result["presence"] = position
+
+        if self.hs.config.use_presence:
+            position = self._presence_id_gen.get_current_token()
+            result["presence"] = position
+
         return result
 
     def process_replication_rows(self, stream_name, token, rows):