diff --git a/changelogs/fragments/51602-ec2_instance_single_iface_description.yaml b/changelogs/fragments/51602-ec2_instance_single_iface_description.yaml
new file mode 100644
index 00000000000..cffa4c6c105
--- /dev/null
+++ b/changelogs/fragments/51602-ec2_instance_single_iface_description.yaml
@@ -0,0 +1,2 @@
+bugfixes:
+  - ec2_instance - Correctly adds description when adding a single ENI to the instance
diff --git a/lib/ansible/modules/cloud/amazon/ec2_instance.py b/lib/ansible/modules/cloud/amazon/ec2_instance.py
index 345b8660cc9..5b5a3f2144b 100644
--- a/lib/ansible/modules/cloud/amazon/ec2_instance.py
+++ b/lib/ansible/modules/cloud/amazon/ec2_instance.py
@@ -860,6 +860,8 @@ def build_network_spec(params, ec2=None):
                 ec2=ec2
             )
             spec['Groups'] = [g['GroupId'] for g in groups]
+        if network.get('description') is not None:
+            spec['Description'] = network['description']
         # TODO more special snowflake network things
 
         return [spec]