diff --git a/x-pack/test/api_integration/apis/fleet/setup.ts b/x-pack/test/api_integration/apis/fleet/setup.ts
index 4fcf39886e20..82e494b0ab28 100644
--- a/x-pack/test/api_integration/apis/fleet/setup.ts
+++ b/x-pack/test/api_integration/apis/fleet/setup.ts
@@ -11,7 +11,8 @@ export default function ({ getService }: FtrProviderContext) {
   const supertest = getService('supertest');
   const es = getService('es');
 
-  describe('fleet_setup', () => {
+  // FLAKY: https://github.com/elastic/kibana/issues/72053
+  describe.skip('fleet_setup', () => {
     beforeEach(async () => {
       try {
         await es.security.deleteUser({