diff --git a/x-pack/plugins/security_solution/public/common/components/navigation/breadcrumbs/index.test.ts b/x-pack/plugins/security_solution/public/common/components/navigation/breadcrumbs/index.test.ts
index dffc7becaf42..c869df6ad388 100644
--- a/x-pack/plugins/security_solution/public/common/components/navigation/breadcrumbs/index.test.ts
+++ b/x-pack/plugins/security_solution/public/common/components/navigation/breadcrumbs/index.test.ts
@@ -306,6 +306,29 @@ describe('Navigation Breadcrumbs', () => {
         },
       ]);
     });
+
+    test('should set "timeline.isOpen" to false when timeline is open', () => {
+      const breadcrumbs = getBreadcrumbsForRoute(
+        {
+          ...getMockObject('timelines', '/', undefined),
+          timeline: {
+            activeTab: TimelineTabs.query,
+            id: 'TIMELINE_ID',
+            isOpen: true,
+            graphEventId: 'GRAPH_EVENT_ID',
+          },
+        },
+        getUrlForAppMock
+      );
+      expect(breadcrumbs).toEqual([
+        { text: 'Security', href: 'securitySolutionoverview' },
+        {
+          text: 'Timelines',
+          href:
+            "securitySolution:timelines?sourcerer=()&timerange=(global:(linkTo:!(timeline),timerange:(from:'2019-05-16T23:10:43.696Z',fromStr:now-24h,kind:relative,to:'2019-05-17T23:10:43.697Z',toStr:now)),timeline:(linkTo:!(global),timerange:(from:'2019-05-16T23:10:43.696Z',fromStr:now-24h,kind:relative,to:'2019-05-17T23:10:43.697Z',toStr:now)))&timeline=(activeTab:query,graphEventId:GRAPH_EVENT_ID,id:TIMELINE_ID,isOpen:!f)",
+        },
+      ]);
+    });
   });
 
   describe('setBreadcrumbs()', () => {
diff --git a/x-pack/plugins/security_solution/public/common/components/navigation/breadcrumbs/index.ts b/x-pack/plugins/security_solution/public/common/components/navigation/breadcrumbs/index.ts
index 605478900d06..a09945f705c5 100644
--- a/x-pack/plugins/security_solution/public/common/components/navigation/breadcrumbs/index.ts
+++ b/x-pack/plugins/security_solution/public/common/components/navigation/breadcrumbs/index.ts
@@ -61,10 +61,14 @@ const isAdminRoutes = (spyState: RouteSpyState): spyState is AdministrationRoute
 
 // eslint-disable-next-line complexity
 export const getBreadcrumbsForRoute = (
-  object: RouteSpyState & TabNavigationProps,
+  objectParam: RouteSpyState & TabNavigationProps,
   getUrlForApp: GetUrlForApp
 ): ChromeBreadcrumb[] | null => {
-  const spyState: RouteSpyState = omit('navTabs', object);
+  const spyState: RouteSpyState = omit('navTabs', objectParam);
+
+  // Sets `timeline.isOpen` to false in the state to avoid reopening the timeline on breadcrumb click. https://github.com/elastic/kibana/issues/100322
+  const object = { ...objectParam, timeline: { ...objectParam.timeline, isOpen: false } };
+
   const overviewPath = getUrlForApp(APP_ID, { path: SecurityPageName.overview });
   const siemRootBreadcrumb: ChromeBreadcrumb = {
     text: APP_NAME,