diff --git a/changelog.d/11764.bugfix b/changelog.d/11764.bugfix
new file mode 100644
index 000000000..1de5b9c60
--- /dev/null
+++ b/changelog.d/11764.bugfix
@@ -0,0 +1 @@
+Fixes a bug introduced in Synapse 1.50.0rc1 that could cause Matrix clients to be unable to connect to Synapse instances with the 'webclient' resource enabled.
\ No newline at end of file
diff --git a/synapse/app/homeserver.py b/synapse/app/homeserver.py
index 177ce040e..dd76e0732 100644
--- a/synapse/app/homeserver.py
+++ b/synapse/app/homeserver.py
@@ -27,7 +27,6 @@ import synapse
 import synapse.config.logger
 from synapse import events
 from synapse.api.urls import (
-    CLIENT_API_PREFIX,
     FEDERATION_PREFIX,
     LEGACY_MEDIA_PREFIX,
     MEDIA_R0_PREFIX,
@@ -193,7 +192,13 @@ class SynapseHomeServer(HomeServer):
 
             resources.update(
                 {
-                    CLIENT_API_PREFIX: client_resource,
+                    "/_matrix/client/api/v1": client_resource,
+                    "/_matrix/client/r0": client_resource,
+                    "/_matrix/client/v1": client_resource,
+                    "/_matrix/client/v3": client_resource,
+                    "/_matrix/client/unstable": client_resource,
+                    "/_matrix/client/v2_alpha": client_resource,
+                    "/_matrix/client/versions": client_resource,
                     "/.well-known": well_known_resource(self),
                     "/_synapse/admin": AdminRestResource(self),
                     **build_synapse_client_resource_tree(self),